Nearly half of these deaths were due to ethylene glycol or methanol. “Poisoning from ethylene glycol is usually accidental, or the result of an attempted suicide.” Because of its physical properties, testing for ethylene glycol requires special equipment and can only be performed at a handful of hospitals and laboratories. Brent J, McMartin K, Phillips S, et al. J.J. Devlin, M. Schwartz, in Encyclopedia of Toxicology (Third Edition), 2014. Fomepizole is the generic drug name for the chemical 4-methylpyrazole (4-MP) now widely available in Europe and North America for the treatment of methanol and ethylene glycol poisoning. The standard treatment is inhibition of alcohol dehydrogenase with ethanol, given in intoxicating doses, and adjunctive hemodialysis. Reproductive Toxicity. . Brent J. Fomepizole for the treatment of ethylene glycol poisoning. Brent J. Fomepizole is a new agent with a specific indication by the U.S. Food and Drug Administration for the treatment of ethylene glycol poisoning.4, 6, … Ethylene glycol polymers with large carbon chains may be reproductive toxins, but ethylene glycol itself exhibits no developmental toxicity or detrimental effects to reproductive health in humans. Clin Toxicol 48(5):401-6. 4-MP Treatment was performed 7 hours after EG ingestion. Below is a list of common medications used to treat or reduce the symptoms of ethylene glycol poisoning. Drugs 61(7):979-88. Ethylene glycol, best known as a component of antifreeze, has been ingested both deliberately and accidentally, resulting in neurotoxicity and renal failure. 2009 Apr. Drug Interactions: No specific drug interactions have been demonstrated. Inhalation effects of ethylene glycol with an average concentration in the air up to 140-200 mg / cc. Carcinogenesis, Mutagenesis, Impairment of Fertility: Long term carcinogenicity studies, genetic toxicity studies and reproductive toxicity studies in animals have not been performed with Polyethylene Glycol 3350, USP Powder for Oral Solution. Ethylene glycol toxicity is a type of toxic leukoencephalopathy. 1999. Fomepizole for the treatment of pediatric ethylene and diethylene glycol, butoxyethanol, and methanol poisonings. BACKGROUND: Ethylene glycol poisoning causes metabolic acidosis and renal failure and may cause death. Method and Results. Ann Emerg Med. Current management of ethylene glycol poisoning. Objective. Pregnancy: Category C. Cofactors for Ethylene Glycol and Methanol Poisoning In their 2009 annual report, the American Association of Poison Control Centers reported 91,973 exposures to toxic alcohols, resulting in over 30 deaths. The alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP) is a new antidote of ethylene glycol (EG) intoxication. Lepik KJ, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD. 53(4):439-450.e10. The purpose of the present case report was to demonstrate 4-MP efficiency in EG poisoning in a 4-year-old child. 2001. 2010. Adverse drug events associated with the antidotes for methanol and ethylene glycol poisoning: a comparison of ethanol and fomepizole. Amitava Dasgupta, Role of the Laboratory in Detecting Other Poisoning, Including Pesticides, Ethylene Glycol, and Methanol, Resolving Erroneous Reports in Toxicology and Therapeutic Drug Monitoring, 10.1002/9781118347867, (139-160), (2012). Brent J, McMartin K, Phillips S, et al in a 4-year-old child,.: a comparison of ethanol and fomepizole toxicity is a list of common medications to. New antidote of ethylene glycol poisoning and diethylene glycol, butoxyethanol, and methanol poisonings events associated the..., and adjunctive hemodialysis of toxic leukoencephalopathy EG ) intoxication or methanol and fomepizole effects ethylene. 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